Do You Have An Endocannabinoid Deficiency?

By October 31, 2017 April 2nd, 2019 Health & Wellness, Industry News

When NOTHING Else Seems To Be Working, Could You Be Suffering From CED (Clinical Endocannabinoid Deficiency)?

CED (Clinical Endocannabinoid Deficiency)? Wait a minute. Isn’t this made up stoner stuff used to justify your “pot smoking” habits? Let’s be real. How can NOT consuming cannabis put you at risk for all sorts of modern problems?

And the answers to these intense lines of questions are. Yes! CED (Clinical Endocannabinoid Deficiency) is very real! And No. It’s not just some silly thing, a pothead made up, to smoke a “wee-bit” more weed.

Imagine for a moment. What if you never took Vitamin C, in your entire life, because the government made it HIGHLY illegal? What would happen? One of the most common problems that will start to pop up everywhere, with Vitamin C deficiency, is scurvy.

In the eighteenth century, scurvy killed a lot of people. It wasn’t until the turn of the century that they firmly established its cause and treatment. The simple treatment for scurvy is Vitamin C.

Any sort of deficiency, or excess for that matter, has the potential to cause all sorts of problems. Common wisdom tells us to consume EVERYTHING in moderation. Even water, in extreme excess, has to power to kill you. Proper balance is the goal when it comes to most all things in life.

When It Comes To CED (Clinical Endocannabinoid Deficiency) What Questions Will Help Establish Its Validity?

A few basic question you might have on your mind about CED (Clinical Endocannabinoid Deficiency) are as follows:

  • What is CED?
  • How do you know you have CED?
  • Can you measure Endocannabinoid levels?
  • How many diseases are the direct result of this deficiency?
  • What modern diseases would “actually” exist if humanity wasn’t suffering from CED?

What Is Clinical Endocannabinoid Deficiency? (CED)?

Two publications presented in 2001 laid the foundation for the theory of clinical endocannabinoid deficiency (CED). In these publications, Dr. Ethan Russo (neurologist and prominent cannabis research physician who coined the term CED) examines the history of how ancient cultures use medicinal cannabis. Between the years 1842 and 1942, prominent physicians claim to prefer cannabis to any other migraine treatment. We even have Sir William Osler (often considered as the father of modern medicine) assert that cannabis is the most effective treatment for headache disorders (aka migraines).

What is CED?

As the name of the deficiency suggests, CED is having a lack of endocannabinoids. What are endocannabinoids? Endo (meaning internal or within) and cannabinoid. Endocannabinoids are neurotransmitters that work in both the central & peripheral nervous systems by binding to cannabinoid receptors and receptor proteins.

Wondering what the Endocannabinoid System is? It is a homeostatic regulator found in mammals that helps to modulate all other systems in the body. You can read more about it here.

Currently, science has isolated two cannabinoids that originate from within the body.

These two endocannabinoids are 2-AG (2-Arachidonoylglycerol) and Anandamide. The endocannabinoid 2-AG is closely associated with the plant cannabinoid CBD (cannabidiol). And Anandamide (named after the Sanskrit word for bliss) is closely associated with the plant cannabinoid THC (Tetrahydrocannabinol).

How Do You Know You Have CED?

In his 2016 research update, Dr. Ethan Russo tells us CED could arise from many causes including:

  • Genetic.
  • Congenital (present from birth) causes.
  • Progress of another disease.
  • Injury.

In his 2016 update, Dr. Russo lays out the criteria for the greatest evidence of CED. The greatest evidence used to “identify” CED is present in migraine, fibromyalgia, and irritable bowel syndrome. To simplify, what qualifies as CED is as follows:

  • All increased sensitivity to pain (must be clinically diagnosed).
  • Extensive negative diagnoses.
  • Elevated anxiety and depression.
  • Psychosomatic origin (caused by internal conflict or stress).
  • Wastebasket diagnosis (a label skeptical doctors give anxious patients who pressure the doctor for a diagnosis).
  • And more.

Besides going through this TEDIOUS bureaucratic process of trying to find the underlying cause of your discomfort. Are there any other ways to “measureCED? Must this process be mostly subjective or is there a REAL modern test that can specifically measure and accurately conclude that you, in fact, do have clinical endocannabinoid deficiency (CED)?

Can You Measure Endocannabinoid Levels?

Since the discovery of the endocannabinoid system (ECS), in the early 1990’s, science has been performing research. Early research methods for measuring the ECS were complex and invasive. These methods involved cutting into the brain tissue, gathering lipids, and purifying the sample with solvents.

As methods developed, they were able to “minimize” invasive activities with microdialysis techniques. This “newer” microdialysis method involved placing a needle into the brain’s interstitial space. As the needle was in the brain, it would continually measure concentrations of endocannabinoids.

More modern techniques have allowed us to measure endocannabinoid level is human saliva.

How Many Diseases Are The Direct Result Of Endocannabinoid Deficiency?

Three “widely established” major conditions suggest an underlying endocannabinoid deficiency. These three conditions are migraine, fibromyalgia, and irritable bowel syndrome. Patterns uncovered in more of Dr. Russo’s research concludes interesting findings. These three conditions have a primary cause of endocannabinoid deficiency. And can be treated with cannabinoids.

According to research published in the British Journal Of Pharmacology, endocannabinoids play an “important role” in a wide range of areas. These include:

  • Nervous system development.
  • Protecting neurons against disease.
  • Synaptic plasticity (your brain’s ability to strengthen or weaken over time in response to activity level).
  • Pain & reward.
  • Valence (Subjective positive-to-negative evaluation of an experienced state).
  • Arousal.
  • Motivational intensity.
  • And more.

Further research from Dr. Ethan Russo brings to light evidence of other CED related disorders including:

  • Neonatal failure to thrive
  • Cystic fibrosis
  • Causalgia, severe burning pain
  • Brachial plexopathy
  • Phantom limb pain
  • Infantile Colic
  • Glaucoma
  • Dysmenorrhea
  • Hyperemesis gravidarum
  • Unexplained fetal wastage (repetitive miscarriages)
  • Post-traumatic stress disorder (PTSD)
  • Bipolar disease
  • and possibly many others.

Cannabinoids

Dr. Russo suggests that plant cannabinoids can strengthen a weakened endocannabinoid system. That’s because they interact with the Endocannabinoid System much in the same way as our own endocannabinoids do.

What is CBD?

Cannabidiol (CBD) is one of 85 phytocannabinoids known to currently exist in the cannabis plant with an expectation of more to come.

These different phytocannabinoids are known to exist at different levels in different varieties of cannabis.  Most of the cannabinoids don’t exist in large enough concentrations to have any noticeable effect, but CBD concentration can be as high as 40% in CBD-rich cultivars of industrial hemp.

The CBD in our BioCBD+™ products is extracted from our special variety of industrial hemp that contains naturally high concentrations of CBD. The result is a raw oil that is high in CBD, virtually free of THC (less than 0.03%,) and complete with a full spectrum of other cannabinoids and terpenes, which work synergistically to make BioCBD™ even more effective.

What Modern Diseases Would “Actually” Exist If Humanity Wasn’t Suffering From Clinical Endocannabinoid Deficiency (CED)?

As we reach the pinnacle of our investigations into CED, we ask the (potentially) most challenging questions humans have to deal with. What modern diseases would exists if we didn’t have CED? The more we investigate the endocannabinoid system, the more miraculous it appears to be.

Dr. David Allen, a retired cardiac (heart) surgeon and member of the ICRS (International Cannabinoid Research Society said some very interesting things. In another article, we dive deep in discussing Dr. David Allen and the ICRS claims.

To wrap up our investigation with CED, we’ll end with a powerful quote that will keep future doctors “thinking.”

Dr. Allen says, “More people will be saved by the manipulation of the endocannabinoid system than are currently saved by surgery.”

What modern diseases will vanish once the endocannabinoid system is fully understood by future doctors? Only time and good science will tell.

Do you need solutions NOW to support your body’s Endocannabinoid System?  We are here to provide you with the safest, #1 most effective, hemp-derived bioavailable CBD on the market.

It is our mission to help you improve your life and feel better with BioCBD+™products, health tips and more.

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James Sol Radina

About James Sol Radina

As CEO and Co-Founder of BioCBD Plus™, James Sol Radina brings years of experience and accumulated expertise from the CBD industry. His interest originated in early 2014, when James embarked on a major filmmaking project to travel and study CBD around the world. Together with a team of filmmakers, he sought out to interview top doctors, scientists, and researchers about CBD, which, at the time, was relatively lesser known, but was starting a buzz in the market. After seeing first-hand the results that CBD had in the patients and experts they filmed, James was “all in!” and his business pursuits began. James started BioCBD Plus™ in 2015, with the goal to fill a niche void that existed in the CBD industry. With the knowledge he gained through his study of CBD, combined with new scientific research, he created the world’s first water-soluble, 100% BioAvailable CBD. The proprietary formula is whole-plant based and more easily absorbable by the body than other CBD products on the market, and the company’s product suite has continued to expand following its demonstrated success. The strength of James’ passion for CBD is matched by his dedication to volunteer service. He incorporated a strong socially responsible model to BioCBD Plus™, which supports The Veterans Discount Program and other programs through donations of CBD products to those who cannot afford them. Since the start of the company, James has also continued to be the inspirational energy behind the company’s beliefs and marketing strategy, which are driven by his commitment to spreading the science-based truth about CBD and bringing the healing benefits of the product to as many people as possible.

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